Novartis is trading 12.51% down at $139.97 after del-desiran failed to achieve statistically significant improvement in the Phase III HARBOR trial for myotonic dystrophy.

  • Reuters reported this was the company’s second major clinical setback within days, following pelacarsen’s cardiovascular-trial failure.
  • The setbacks are intensifying concerns about Novartis’s growth pipeline.
  • The broader market is only modestly weaker, making the company-specific drug failures the primary catalyst.