MSCI is trading 5.01% down at $574.18 in pre-market on October 22, amid a sharply weaker market backdrop and broad risk-off pressures. - U.S. futures fell as investors reassessed AI spending after megacap earnings; rising Middle East tensions pushed oil higher. - MSCI’s October 20 quarter beat earnings and revenue expectations, and available evidence does not point to a fresh negative company-specific earnings catalyst.