U.S. spot Bitcoin ETFs experienced significant net outflows for the week ending October 16. On October 16, these funds saw a net outflow of $82.39 million. Weekly withdrawals totaled approximately $228 million. Grayscale's GBTC ranked among the most closely watched funds.

October's outflows mark a reversal of September's positive inflows. This suggests a shift in investor sentiment. Through mid-October, Bitcoin ETFs accumulated about $535 million in net outflows for the month. This contrasts with $2.6 billion of new capital that entered the funds in September. Sustained selling pressure indicates a more cautious or bearish investor stance toward Bitcoin exposure through these regulated products.