enGene Holdings is trading at $1.72, up 5.52%, alongside biotech-sector strength; XBI was up 3.64% pre-market. - No new company-specific announcement explaining the October 22 pre-market move surfaced in the search; latest company coverage concerned an October 15 webinar and previously reported trial data. - Broader U.S. futures were lower, and pre-market volume or activity details were unavailable in the sources reviewed.